Diagnostic Role of Tumour Markers CEA, CA15-3, CA19-9 and CA125 in Lung Cancer     

Indranath Ghosh  Debojyoti Bhattacharjee  Anjan Kumar Das  Goutam Chakrabarti  Anindya Dasgupta  Subir Kumar Dey 《Indian journal of clinical biochemistry : IJCB》2013,28(1):24-29

The aim of this study was to assess the diagnostic yield of the tumour markers carcinoembryonic antigen, carbohydrate antigen 15-3, carbohydrate antigen 19-9 and carbohydrate antigen 125, in serum and bronchoalveolar lavage fluid in a group of patients with bronchogenic carcinoma. Serum and bronchoalveolar lavage fluid samples were collected in a group of 90 patients with benign or malignant pulmonary diseases. After appropriate processing, tumour markers were determined by enzyme immunoassay. The diagnostic yields (sensitivity, specificity and predictive values) in each environment (serum and bronchoalveolar lavage fluid) were obtained by using "Receivers operating characteristic" curve. Determined individually, carcinoembryonic antigen, carbohydrate antigen 19-9 and carbohydrate antigen 125, showed the greatest diagnostic accuracy in bronchoalveolar lavage fluid. Carbohydrate antigen 15-3 did so in serum. Carcinoembryonic antigen was the most relevant marker in bronchoalveolar lavage fluid. For the factors evaluated in this study, determination of carcinoembryonic antigen, carbohydrate antigen 19-9 and carbohydrate antigen 125 in bronchoalveolar lavage fluid were clinically more useful markers in comparison with serum, although the latter may also be helpful in certain situations. Although there is no specific tumour marker for lung cancer, the combination of several can be used to diagnose most patients with lung cancer and also to rule out false positive and negative cases.  相似文献   

Evaluation of Sweat Production by Pilocarpine Iontophoresis: A Noninvasive Screening Tool for Hypohidrosis in Ectodermal Dysplasia     

Surupa Basu  Monjori Mitra  Apurba Ghosh 《Indian journal of clinical biochemistry : IJCB》2013,28(4):433-435

Ectodermal dysplasia (ED) is a genetic disorder affecting the skin, hair, nails, teeth and sweat glands. The clinical presentation is heterogenous; however, hypohidrotic (reduced sweat) ectodermal dysplasia (HED) being the commonest. Also known as anhidrotic ED, sweat glands are sparse or rudimentary, leading to dysregulation of body temperature and episodes of uncontrolled hyperthermia due to reduced sweating. Of the many aids to document hypohidrosis in HED, we present here the technique of pilocarpine iontophoresis to induce, collect and measure sweat. Evaluation of sweat generated (against normally obtained values) is a non-invasive alternative to establish hypohidrosis in disorders such as HED. This augments clinical decision levels to plan skin biopsy for confirmation of diagnosis and facilitates patient management and early discharge. We present two cases of HED that were primarily diagnosed with sweat gland dysplasia using pilocarpine iontophoresis, and later confirmed with skin biopsy findings.  相似文献   

Nature watch     

Dipanjan Ghosh  Ayan Mondal 《Resonance》2016,21(2):173-188

The Sunderbans is the largest mangrove vegetation in the world. Changes in the environment, particularly driven by climate change, forewarn us of the dwindling diversity of exclusive mangrove plants and the charismatic animal species–especially the tiger. The Sunderbans, with its fast-changing geomorphic and hydrological character, is creeping towards its doomsday.  相似文献   

Effect of insulin on serum lipids in relation to nutritional status in diabetics     

G. P. Das  B. Mandal  P. Ghosh  C. R. Maity 《Indian journal of clinical biochemistry : IJCB》1993,8(1):39-43

Serum levels of cholesterol, triglyceride, free fatty acid (FFA) and high density lipoprotein (HDL) cholesterol were studied in 10 undernourished and 10 better nourished diabetic patients at different periods of insulin treatment and in non-diabetic controls. Serum concentrations of cholesterol, triglyceride and FFA were significantly higher in untreated diabetic patients than in control but the elevated lipid levels gradually shifted towards normal on insulin treatment. The HDL cholesterol, on the other hand, was significantly lower in untreated diabetic subjects than those in controls and the HDL cholesterol also gradually modified on insulin therapy. However, the improvement of all the lipid parameters on insulin treatment was somewhat delayed in undernourished compared to those of better nourished diabetics. These results, therefore, suggest that malnutrition interferes with the serum lipid improvement in diabetics on insulin treatment and may make them more prone to develop vascular complications.  相似文献   

The RC circuit: An approach with Fourier transforms     

Mitrajyoti Ghosh 《Resonance》2016,21(11):1029-1042

In this article we shall mathematically analyse the Resistor-Capacitor (RC) circuit with the help of Fourier transforms (FT). This very general technique gives us a lot of insight into solving first order differential equations with source terms depending on time. In itself, the RC circuit is by far the most commonplace entity in modern electronics. But the method of FT is not the accepted custom for an electronic engineer, who is probably more comfortable working with complex impedances and phasors while solving problems in network analysis. In fact, what is used much more extensively is the Laplace transform. But a lot of things, (including the complex impedance itself, and some insight into complex analysis) can be understood better if we use the FT approach to solve the differential equations that come up in network analysis. The use of FT comes smoothly from first principles — precisely what we set out to demonstrate here.  相似文献   

Dalhousie,Charles Wood and the Education Despatch of 1854     

Suresh Chandra Ghosh 《History of education》2013,42(2):37-47

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New educational technologies: Their impact on relationships of dependence and interdependence for Third World countries     

Ratna Ghosh 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1987,33(1):33-50

The widening gap between North and South is more than economic: it is a knowledge and power gap. The influence of the present information revolution on education in the West, unprecedented in its rate and scope of expansion, is increasing the information gap at an alarming rate. Should Third World countries use new educational technologies (NET) as a tool for development? Can they afford it? Will borrowing NET perpetuate the present dependency of the Third World? This paper argues that Third World countries will continue to be technologically dependent because of research and development in the West. The solution lies in the balance of power theory — selective transfer of NET appropriate for their level of development, to strengthen their bargaining position. Mass education and the development of indigenous technological capacity are implied. Bargaining capacity would reduce dependency, create greater interdependence and change the equation of power.  相似文献   

The effects of passive and active learning on student preference and performance in an undergraduate basic science course     

Minhas PS  Ghosh A  Swanzy L 《Anatomical sciences education》2012,5(4):200-207

Active learning is based on self-directed and autonomous teaching methods, whereas passive learning is grounded in instructor taught lectures. An animal physiology course was studied over a two-year period (Year 1, n = 42 students; Year 2, n = 30 students) to determine the effects of student-led seminar (andragogical) and lecture (pedagogical) teaching methods on students' retention of information and performance. For each year of the study, the course was divided into two time periods. The first half was dedicated to instructor-led lectures, followed by a control survey in which the students rated the efficiency of pedagogical learning on a five-point Likert scale from one (strongly disagree) to five (strongly agree). During the second period, students engaged in andragogical learning via peer-led seminars. An experimental survey was then administered to students using the same scale as above to determine students' preferred teaching method. Raw examination scores and survey results from both halves of the course were statistically analyzed by ANOVA with Newman-Keuls multiple comparison test. By the end of the study, student preference for peer-led seminars increased [mean ± SD: (2.47 ± 0.94)/(4.03 ± 1.36), P < 0.04], and examination scores significantly increased [mean ± SD: (73.91% ± 13.18)/(85.77 ± 5.22), P < 0.001]. A majority of students (68.8%) preferred a method that contained peer-led seminars and instructor-led lectures. These results may indicate that integration of active and passive learning into undergraduate courses may have greater benefit in terms of student preference and performance than either method alone.  相似文献   

Glossopterids: Suzerains of geologically past Indian forests     

Dipanjan Ghosh 《Resonance》2000,5(3):60-65

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Evolving strategies in whirlwind mode: The changing face of anatomy education during Covid-19 pandemic     

Sanjib Kumar Ghosh 《Anatomical sciences education》2022,15(6):1103-1119

The Covid-19 pandemic stipulated adoption of unfamiliar strategies for delivering anatomy education in online mode. The factors which determine education strategies are variable across geographical regions. It was perceived that an overview of education strategies around the globe would be useful for anatomists. Hence this narrative review was undertaken to collate observations from different geographical regions pertaining to education strategies adopted during the pandemic. Data relevant to the topic of study were extracted from 12 articles that were selected from an initial pool of 317 articles based on search criteria set for the review. Subtle differences in core education strategies implied that baseline response from anatomists was similar across regions. It was evident that online digital tools were key elements of education strategies adopted by educators for delivering online anatomy classes across the globe. Interestingly, a considerable gap in terms of number and variety of online tools used for anatomy education (those requiring commercial purchase) was noted between economically developed and developing regions. This may have an impact on learning outcome for students and may even lead to variations in anatomical knowledge by regions. It was observed that offline human dissection sessions were incorporated into online practical classes in one region as positive cases showed a declining trend. This positive development is worth emulating elsewhere based on cautious assessment of prevailing situation. From a broad perspective timely introduction of education strategies ensured delivery of anatomy education during the pandemic and gave an evolved outlook to the fabric of anatomy education.  相似文献